KPV in mouse intestinal tumor models
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
Viennois E, Ingersoll SA, Ayyadurai S, Zhao Y, Wang L, Zhang M, Han MK, Garg P, Xiao B, Merlin D. · Cellular and molecular gastroenterology and hepatology
Study record
- Population
Wild-type and genetically modified mice; human colon-tissue samples were examined for transporter expression, not treated with KPV.
Read source · Full-text reportMethods — Mice; Results — PepT1-dependent KPV effects- Formulation
KPV reagent from Biopeptide, diluted in drinking water.
Read source · Full-text reportMethods — Colitis-Associated Cancer and Intestinal Adenoma Spontaneous Models- Route
Drinking water in mice.
Read source · Full-text reportMethods — Colitis-Associated Cancer and Intestinal Adenoma Spontaneous Models- Dose & frequency
100 μmol/L in drinking water during specified experimental periods; concentration is not an administered mg/kg dose and establishes no human or KLOW regimen.
Read source · Full-text reportMethods — Colitis-Associated Cancer and Intestinal Adenoma Spontaneous Models- Study design
AOM/DSS inflammatory tumor models and an ApcMin/+ spontaneous adenoma model; PepT1 genetics tested transporter dependence.
Read source · Full-text reportMethods — Mice; Colitis-Associated Cancer and Intestinal Adenoma Spontaneous Models- Duration
AOM/DSS protocol gave KPV during two seven-day DSS cycles separated by recovery; ApcMin/+ animals received KPV from ages five to 18 weeks.
Read source · Full-text reportMethods — Colitis-Associated Cancer and Intestinal Adenoma Spontaneous Models- Reported findings
Reduced tumor and inflammation measures in selected mouse experiments; benefits depended on PepT1 in the inflammatory model.
Read source · Full-text reportResults — KPV Prevents Intestinal Inflammation and Tumorigenesis- Adverse events
No human treatment or human safety study. The study does not establish cancer-treatment safety or efficacy in people.
Read source · Full-text reportMethods; Results- Monitoring
Daily weight during DSS exposure; terminal tumor counts, histology and molecular analyses.
Read source · Full-text reportMethods — Colitis-Associated Cancer and Intestinal Adenoma Spontaneous Models
What it supports
Experimental evidence linking PepT1 and KPV effects in intestinal tumor models.
What it does not establish
Human biopsy observations are not human KPV treatment results. Different genotypes and disease models used different experimental conditions. Not evidence for human cancer prevention or KLOW.
Funding
Veterans Affairs, NIDDK and Crohn’s & Colitis Foundation support (Funding).
Literature search cutoff: 2026-09-08 · Not independently clinically reviewed
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